Anti-MMP-3, N-terminus

Description_x000D_ General description_x000D_ MMP-3 (matrix metalloproteinase-3), also known as stromelysin-1, is a member of the matrix metalloproteinase (MMP) family of zinc endopeptidases. MMP’s are required for removal of extracellular matrix machinery during embryo development, morphogenesis and tissue remodeling. Endogenous tissue inhibitors of metalloproteinases (TIMPs) are responsible for regulating MMP-3. Any disruption of this system can cause diseases such as arthritis, metastasis, atherosclerosis and tumor growth._x000D_ Specificity_x000D_ Other homologies: Mouse and rat (64% sequence homology)._x000D_ This antibody recognizes MMP-3 at the N-terminus._x000D_ Immunogen_x000D_ Epitope: N-terminus_x000D_ KLH-conjugated linear peptide corresponding to human N-terminal MMP-3._x000D_ Application_x000D_ Detect MMP-3 using this Anti-MMP-3 Antibody, N-terminus validated for use in WB, IH(P)._x000D_ Immunohistochemistry Analysis: A 1:600 dilution from a previous lot detected MMP-3 in colorectal carcinoma and ductal carcinoma tissues._x000D_ Research Category_x000D_ Cell Structure_x000D_ Research Sub Category_x000D_ MMPs & TIMPs_x000D_ Target description_x000D_ ~58 kDa observed._x000D_ An uncharacterized band may be seen at ~78 kDa_x000D_ Physical form_x000D_ Affinity Purfied_x000D_ Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide._x000D_ Storage and Stability_x000D_ Stable for 1 year at 2-8°C from date of receipt._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Quality_x000D_ Evaluated by Western Blot in PMA-treated HL-60 concentrated media._x000D_ Western Blot Analysis: 0.1-1 µg/mL of this antibody detects MMP-3 in 10 µg of PMA-treated HL-60 concentrated media._x000D_ Linkage_x000D_ Replaces: AB812_x000D_ Analysis Note_x000D_ Control_x000D_ PMA-treated HL-60 concentrated media_x000D_ Other Notes_x000D_ Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.